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Calendar Year 2008 Presentations

Ultrashort Pulsed Laser Applications in Biomedicine
Greg Spooner, Raydiance

Wednesday, January 16, 2008, 7:30pm
Clark Center Auditorium

Lasers heat things up. Modifying materials with lasers frequently, though not always, involves a thermal interaction produced through linear absorption. High peak power and ultrashort pulsed lasers are different. They can produce non-linear effects, which may be used to affect materials in a minimally or even non-thermal way. The unique interactions associated with ultrashort pulsed lasers enable medical therapies and techniques that are unique.

I will review the basics of ultrashort pulse laser material interactions, describe the application of these interactions to biological tissues and materials, and will present a few examples of ultrashort pulse laser applications in biomedicine I have been involved with over the last 10 years. Selected video and images of surgeries and tissue interactions will be shown to illustrate these applications.

Greg Spooner studied condensed matter physics and IR spectroscopy at UC Davis. Immediately after obtaining a Ph.D. in 1992, he began a career in lasers, medicine, and laser medicine. A major thread in his career is the use of picosecond and femtosecond lasers in medical therapies and surgeries. His resume includes a 5-year stints at Coherent Medical, the University of Michigan's Center for Ultrafast Optical Science, Intralase, and Cutera. Dr. Spooner recently joined Raydiance, a commercializer of ultrashort pulse laser platforms.

Starting and Building a Winning Medtech Business
J. Casey McGlynn
Wilson Sonsini Goodrich & Rosati

Wednesday, February 20, 2008, 7:30pm
Clark Center Auditorium
Optional Dinner, Stanford Hospital Cafeteria, 6:15pm (no reservations)

This talk will focus on starting and building a winning medtech business. Among other topics, it will address:

a... The Idea. How do you get your idea out of the university and into a company? What types of ideas are most fundable? What do you need to do to protect your idea, and what things can wait until after funding?
b... Funding. Is angel or venture capital the best way to go? How developed does the idea need to be in order to attract capital? What are some successful strategies for finding money? How should the investment be structured?
c... The Team. What members of the team are needed to get the enterprise started? Where do you go to find the right people?
d... Growing the Business. How do you go about building a winning culture? How do you make sure the enterprise is capital efficient? How should you manage you board?
e... Selling the Business. What are some successful strategies in selling your business? How should the deal be structured?

J. Casey McGlynn joined Wilson Sonsini Goodrich & Rosati in 1978 and formed the Life Sciences Group at the firm in 1990. It is a nationally recognized leader in the representation of startup and emerging growth companies in the life sciences field. Mr. McGlynn has one of the largest practices in the country focused on Medical Devices.

Mr. McGlynn has formed, sold and taken public many of the most important medical device companies started during the last 25 years. These companies include Anatros Corporation (predecessor to Tyco's IV business), Advanced Cardiovascular Systems and Devices for Vascular Interventions (predecessors to Guidant's vascular business, now Abbott Vascular), Aneurx (predecessor to Medtronic's Aortic Aneurism business), Arthrocare (ARTC), Biopsys Medical (predecessor to JNJ's women's health business), Cardiac Pathways (now part of BSX's EP catheter business), Cardiothoracic Systems (predecessor to Guidant's cardiac surgery business), Conor MedSystems (now part of Cordis/JNJ), Cutera (CUTR), CVIS (predecessor to BSX's vascular ultrasound business), FoxHollow Technologies (now part of ev3's peripheral vascular business), Fusion Medical (predecessor to Baxter's surgical sealant business), HeartStream (predecessor to Phillips' external defibrillator business), Kyphon (acquired by Medtronic), Perclose (predecessor to Abbott's vascular closure business), Somnus Medical (predecessor to Gyrus' ENT business), Spinal Concepts (predecessor to Abbott's orthopedics business), Ventana Medical Systems (VMSI), and Ventritex (predecessor to St Jude's CRM business).

Robotically Assisted Surgery:
How daVinci Works Now
and How It Could Evolve

William C. Nowlin, Ph.D
Intuitive Surgical

Wednesday, March 19, 2008, 7:30pm
Clark Center Auditorium
Optional Dinner, Stanford Hospital Cafeteria, 6:15pm (no reservations)

Intuitive Surgical makes the daVinci(tm) Surgical System, which is variously described as a "robot", a "telesurgical system", and a "mechanism for minimally invasive surgery". In this presentation, I'll give a general introduction to the device and how surgery is accomplished using it. I'll talk a little about the business of robotic surgery. I'll try to give some historical background to credit those on whose shoulders we stand, and describe the fundamental technological elements (what's neat about it). Next I'll discuss the technical and business challenges, and I'll do my best to describe where I see the technology going in the next few years. I promise plenty of pictures, videos, and I hope to bring some hardware to let you explore. The talk can be very interactive, and I am happy to veer off in a direction determined by the group.

Dr. Nowlin joined Intuitive Surgical in 1996 from SRI International, where he was involved in developing SRI's prototype surgical system. Dr. Nowlin became part of Intuitive SurgicalŐs system software leadership team in 1999, then was promoted to Director in 2001 and Senior Director in 2006. Dr. Nowlin received his B.A. in Mathematics and Physics from the University of Virginia, where he was honored by each department as its outstanding graduate; he then received a Masters Degree and Ph.D. in Applied Mathematics from Harvard University, with an application in robotics. Dr. Nowlin is co-author of more than a dozen U.S. and international patents, as well as several technical conference and journal publications.

Realistic Medical Device Implant Simulation
By Metin Ozen, David Wagner and Can Ozcan - OZEN ENGINEERING, INC.

Wednesday, April 16, 2008, 7:30pm
NOTE THIS CHANGE: Room M-114, Stanford Medical School
Optional Dinner, Stanford Hospital Cafeteria, 6:15pm (no host, no reservations)

Computer Aided Engineering (CAE) has captured many physics through Finite Element Analysis (FEA) and Computational Fluid Dynamics (CFD). However, when a human body is involved, the equations get very complicated and it becomes almost impossible to use just FEA and/or CFD. This is when engineers and scientists need muscular-skeletal modeling coupled with FEA. A demonstration of the "AnyBody" interface and modeling capabilities will be presented. "AnyBody" is a multibody dynamics system in which the user can build and analyze models of mechanism. Currently available models, including a whole body model with over 450 muscles, will be reviewed. A simplified upper extremity model will be developed and analyzed as a method for further demonstrating the types of analyses that can be performed with the AnyBody modeling software. In addition, a demonstration of the Any2Ans and Ansys will be presented where data from AnyBody will be brought into Ansys to be able to realistically simulate performance of medical device implants. A spinal implant example will be shown.

About the speakers:
Metin Ozen BS, MS, from Lehigh University and PhD from University of Connecticut. Dr. Ozen is a member of ASME and IEEE. He is an ASME Fellow. His company is a distributor for ANSYS and AnyBody software and the company also provides consulting services in simulation.
David Wagner BS from University of California, Berkeley and MS, PhD from University of Michigan, Ann Arbor. Dr. Wagner is a member of SAE. He is currently a project manager at OZEN ENGINEERING, INC.
Can Ozcan BS and MS from Bosphorus University in Mechanical Engineering. Mr. Ozcan is a project manager at OZEN ENGINEERING, INC.

Hearing Aid Signal Processing and Its Impact on Cognitive Function

by Dr Brent Edwards, Starkey Hearing Research Center, Berkeley, CA

Wednesday, May 21, 2008, 7:30 pm
Clark Center auditorium, Stanford University
Optional Dinner, Stanford Hospital Cafeteria, 6:15 pm (no host, no reservations)

Complex processing in the brain plays an important role in hearing. The brain builds up a representation of the world by sophisticated analysis of signals from the cochlea, and from this representation it focuses attention on the auditory objects that it wishes to analyze and interpret. Understanding how hearing impairment and hearing aid signal processing affect such cognitive ability is critical to better design and fit hearing aids. In this talk, the current state of hearing aid technology will be reviewed. Cognitive aspects of attention, effort, and auditory scene analysis ability will be reviewed from the perspective of how hearing impairment and hearing aid technology may affect these abilities. Results from our current research will be presented that clearly prove our hypotheses on the interaction of hearing aid processing and cognitive function, and the impact of these interactions on speech understanding will be discussed.

Brent Edwards completed his Ph.D. in Electrical Engineering at the University of Michigan in 1992 where he investigated the application of signal processing techniques to the human auditory system. He followed this with a postdoctoral fellowship in Psychology at the University of Minnesota where he conducted psychoacoustic research and taught in the University's Department of Communication Disorders. Dr. Edwards was with GN ReSound from 1995 to 2000 where he was the Director of Research in charge of signal processing development and hearing science, during which time GN ReSound developed the world's first programmable DSP chip for hearing aids. He was with the startup company Sound ID from 2000 to 2004 as Vice President of Research where he developed products that integrated wireless technology with hearing aid technology for consumer applications. Dr. Edwards joined Starkey Laboratories in 2004 where he is currently Vice President of Research, located at the Starkey Hearing Research Center in Berkeley, California--a center created to conduct fundamental research on perception by the hearing impaired and on new ideas for hearing aid technology. Dr. Edwards speaks worldwide on hearing science and hearing aid research.

Wednesday, June 18, 2008, 7:30pm Clark Center auditorium, Stanford University Optional Dinner, Stanford Hospital Cafeteria, 6:15 pm (no host, no reservations)

Progress on the Development of an Artificial Pancreas
by Geoffrey McGarraugh, TheraSense Inc./Abbott Diabetes Care

The components to create an artificial pancreas for the treatment of diabetes exist today. The Juvenile Diabetes Research Foundation, the leading charitable funder of diabetes research, has initiated an effort to coordinate industry, clinicians, academics and the FDA to hasten the development of a commercial artificial pancreas. The seminar will outline the challenges of treating diabetes and the promising improvements an artificial pancreas could bring. The components for creating the artificial pancreas -- the insulin(s), the insulin pump, and the continuous glucose monitor - will be reviewed with particular emphasis on their strengths and limitations. The approaches to the development of the last component -- the controller -- will be described, and the some early clinical studies of the control algorithms will be reviewed.

Geoffrey McGarraugh is the Directory of Chemistry at Abbot Diabetes Care which acquired TheraSense Inc where he led development of the FreeStyle (tm) Blood Glucose Monitor and the Navigator (tm) Continuos Glucose Monitoring system. He has worked on many seminal glucose monitoring projects from feasibility to commercialization. He has twenty-nine US and international patents in the field of glucose monitoring. He previously worked at LifeScan, A Johnson & Johnson Company where he co-invented the One Touch (tm) Blood Glucose Monitor, the first glucose monitor that eliminated user technique. He has an M.S. in Chemistry from University of California, Santa Cruz and a B.S. from University of California, Los Angeles.

Wednesday, September 17, 2008, 7:30pm Clark Center auditorium, Stanford University Optional Dinner, Stanford Hospital Cafeteria, 6:15 pm (no host, no reservations)

Applied Innovation: How to find the next big thing in MedTech
by Joshua Makower, M.D., CEO, ExploraMed Development, LLC.

So you'd like to do something with your career that will make the world a better place for patients,. but where do you start? How do you find the next big opportunity in Medtech? Dr. Makower will share with you the secrets of the Stanford Biodesign Innovation Process and show how he has applied these same principles to help create new companies in several medical fields.

Joshua Makower, M.D. is the Founder & Chief Executive Officer of ExploraMed Development, LLC, a medical device incubator based on the west coast and is also a Venture Partner with New Enterprise Associates. Dr. Makower serves as a Consulting Associate Professor of Medicine at Stanford University Medical School and is Co-Founder of Stanford's Biodesign Innovation Program. Prior to this, he was Founder, Chairman and Chief Technical Officer of TransVascular, Inc. a company focused on the development of a completely catheter-based coronary bypass technology, which was acquired by Medtronic, Inc. in 2003, and Founder and Chairman of EndoMatrix, Inc., a company focused on the development of a novel therapy for incontinence and GI Reflux, which was acquired by C.R. Bard in 1997. Up until 1995, Dr. Makower was Founder and Manager of Pfizer's Strategic Innovation Group, a group chartered to create new medical device technologies and businesses for Pfizer's medical devices businesses. Dr. Makower holds over four dozen patents for various medical devices in the fields of Cardiology, ENT, General Surgery, Drug Delivery, Orthopaedics and Urology. Dr. Makower holds a Masters of Business Administration degree from Columbia University, a Doctor of Medicine degree from the New York University School of Medicine, and a Bachelor of Science degree in Mechanical Engineering from the Massachusetts Institute of Technology. Dr. Makower also serves as Chairman of the Board for Acclarent, Inc., NeoTract, Inc, Vibrynt, Inc. and moximed, Inc. - ExploraMed's most recent spin outs, and on the Board of Directors for Intrinsic Therapeutics, Inc. - a venture backed private company developing innovative spinal therapies.

Wednesday, October 15, 2008, 7:30pm Clark Center auditorium, Stanford University Optional Dinner, Stanford Hospital Cafeteria, 6:15 pm (no host, no reservations)

Advances and Future Directions in Radiation Medicine
by Martin Kandes, Director, International Sales Operations, Varian Medical Systems

Mr. Kandes will discuss technology innovations in radiation medicine that have enabled progress towards the goal of making cancer a manageable chronic disease. He will also discuss the current situation and point generally towards future directions on the horizon.

Martin Kandes has been with Varian Medical Systems for over 26 years, serving in a wide variety of marketing, planning, product development, and system integration, simulation and treatment planning efforts. Prior to his career at Varian, he was the Chief Medical Physicist at the Palo Alto Medical Clinic and at Hartford Hospital.

He graduated from California State College, PA, received an MPH from Yale University, an MSc in Medical Physics from Harvard University, and an MBA from Golden Gate University.

Wednesday, November 19, 2008, 7:30pm Clark Center auditorium, Stanford University NEW DINNER LOCATION: Optional Dinner, Nexus cafeteria in the Clark Center, 6:15 pm (no host, no reservations)

Digital Humans: From Biomechanical Models to Simulated Surgery
Scott L. Delp, Ph.D. Charles Lee Powell Professor Bioengineering, Mechanical Engineering and Orthopaedic Surgery Stanford University

Abstract of Presentation
The outcomes of surgeries performed to improve musculoskeletal function are unpredictable. This problem exists, in part, because the development and testing of new surgical techniques rely almost entirely on clinical trials (i.e., trying surgeries on patients), in which the means to quantify surgical changes or predict postoperative results do not exist. I believe that the design and analysis of surgeries will proceed more effectively if computer models are developed that predict the functional consequences of surgical interventions. My students and I have developed computer graphics models to simulate the biomechanical consequences of bone reconstructions, muscle-tendon surgeries, and joint replacements. This presentation will review the results of our dynamic simulations of movement that have been used to design surgical procedures used in the management of cerebral palsy and osteoarthritis. I also will outline some of the major challenges that arise in development of biomechanical simulations of individual subjects.

Scott L. Delp graduated summa cum laude with a B.S. in mechanical engineering from Colorado State University in 1983. He worked in Hewlett Packard's graphics workstation group before beginning graduate school at Stanford University in 1985. Delp received the M.S. and Ph.D. degrees in mechanical engineering from Stanford University in 1986 and 1990 and then joined the faculty of Northwestern University. He returned to Stanford in 1999, where he served as Chairman of the Biomechanical Engineering Division in the Mechanical Engineering Department. In 2002, Delp became the founding Chairman of Stanford's Bioengineering Department.

Delp's work draws on computational mechanics, biomedical imaging, and neuromuscular biology to improve treatments for individuals with physical disabilities. He led the development of a software system that enables modeling and simulation of complex human and animal movements; this software is now used at hundreds of research centers around the world. Computer models that he and his colleagues have developed have helped provide a scientific basis to better treat movement disorders resulting from osteoarthritis, cerebral palsy and stroke.

Professor Delp has received numerous awards for his work, including a National Young Investigator Award from the National Science Foundation, Faculty Fellowships from the Baxter Foundation and Powell Foundation, and a Technology Reinvestment Award for which he was honored at the White House with former President Clinton. He is currently the Charles Lee Powell Professor of Bioengineering, Mechanical Engineering, and Orthopaedic Surgery at Stanford University.

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