Citotoxicidad de Hidroxiapatita y su morfología en composites con Ti (Cytotoxicity of hydroxyapatite and morphology in composites with Ti)

Romina Comín (, Laura A. Reyna (, Mariana P. Cid (, Carlos R. Oldani (), Nancy A. Salvatierra (

Universidad Nacional de Córdoba
This paper appears in: Revista IEEE América Latina

Publication Date: Feb. 2013
Volume: 11,   Issue: 1 
ISSN: 1548-0992

Hydroxyapatite (Ca10(PO4)6(OH)2 is the material used to improve osseointegration of implants in humans. Traditionally Ti-based implant is coated with hydroxyapatite, but this presents several problems such as, low fracture toughness of hydroxyapatite, generation of interfacial cracks during the deposition step and low adhesion ceramic /metal. Furthermore some studies reported that some excellent Ti‑HA bio-composites could be fabricated by the powder metallurgy (PM) technology. In present study it was investigate the cytotoxicity of coralline and bovine hydroxyapatite. Topography of Ti-HA composites obtained by powder metallurgy was evaluated by scanning electron microscopy. The results showed that HA samples analyzed did not affect cell viability. Furthermore, a good integration of HA to the matrix of Ti was observed by microscopy studies

Index Terms:
Hydroxyapatite, Ti-HA composites, biocompatibility, powder metallurgy   

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