Sistema de láser de diodo para la aplicación de Terapia fotodinámica Intersticial (Laser Diode System For Interstitial Photodynamic Therapy)

Laura Pacheco Rodríguez (laurapacheco_88@hotmail.com), Suren Stolik Isakina (sstolik@ipn.mx), José Manuel De la Rosa Vázquez (mdelaros@ipn.mx), Alejandro De la Cadena Perez Gallardo (a.delacpg@gmail.com)


Instituto Politécnico Nacional
This paper appears in: Revista IEEE América Latina

Publication Date: June 2014
Volume: 12,   Issue: 4 
ISSN: 1548-0992


Abstract:
Interstitial Photodynamic Therapy (IPDT) is a promising form of treatment of deep-seated and bulky malignant tumors, based on the lethal cell response to the photochemical reactions when drug is light activated at presence of oxygen. After intravenous administration, the drug is retained selectively by malignant cells, and then, the light is delivered to the target tissue through multiple optical fibers. In order to accomplish an effective internal illumination, laser sources are preferably used because of two important reasons: the laser beam is easily focused to optical fibers, and the monochromatic light can be confined to the narrow absorption band of the drug. In this work we present the design of an irradiation laser system, which involves a 635nm laser diode and a delivering fiber system, for 5-ALA mediated IPDT

Index Terms:
Interstitial Photodynamic Therapy (IPDT), laser diode, optical fiber, 5-Aminolevulinic acid   


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