Control de la temperatura en la formulación de medicamentos inyectables basado en modificaciones al predictor de Smith (Temperature Control Based on a Modified Smith Predictor for Injectable Drug Formulations)

Ivón Oristela Benitez González (novi@electrica.cujae.edu.cu)1, Raúl Rivas Perez (rivas@electrica.cujae.edu.cu)1, Vicente Feliu Batlle (Vicente.Feliu@uclm.es)2, Fernando José Castillo Garcia (Fernado.Castillo@uclm.es)2


1Departamento de Automática y Computación. Instituto Superior Politécnico José Antonio Echeverría
2Escuela Técnica Superior de Ingenieros Industriales, Universidad de Castilla-La Mancha

This paper appears in: Revista IEEE América Latina

Publication Date: April 2015
Volume: 13,   Issue: 4 
ISSN: 1548-0992


Abstract:
This paper proposes a modified Smith predictor scheme for temperature control during the formulation of injectable drugs in chemical reactors. The dynamic model of this process is obtained from an identification procedure applied in a real chemical reactor of the pharmaceutical industry. This identification procedure yields a second order with dominant time delay transfer function. A PI controller combined with a modified Smith predictor is therefore designed which behaves robustly against the effect of measured or unmeasured external disturbances. Simulated results compare the performance of the proposed controller with a standard PI controller, also combined with a conventional Smith predictor, and with Astrom modified Smith predictor. Four performance indexes have been used in this comparison: three related to the output performance (settling time, overshooting, and IAE), and a fourth one related to the control effort (EU). The analysis of these indexes shows that the proposed controller provides lower values of the compared indexes.

Index Terms:
modified Smith predictor, time delay, chemical reactor, injectable drug formulation   


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