Control Robusto Para el Control de Microorganismos en un Bioreactor (Robust Control for cultivation of microorganisms in a high density fed-batch bioreactor)

Abraham E. Rodríguez (, Jorge Antonio Torres Muñoz (, Ricardo Luna (, José Ricardo Pérez Correa (, A.R. Domínguez Bocanegra (, Hebert Sira Ramírez (, R Castro (

1Centro de Investigación y de Estudios Avanzados (CINVESTAV)
2Pontificia Universidad Católica de Chile
3Tecnológico de Estudios Superiores de Ecatepec

This paper appears in: Revista IEEE América Latina

Publication Date: June 2015
Volume: 13,   Issue: 6 
ISSN: 1548-0992

In this paper a nonlinear algorithm for adaptive control of a fed-batch bioreactor for high density cultures is proposed. The control of these processes is difficult due to parameter variations and process disturbances. The control scheme is based on a reduced model used to estimate the uncertainties with adaptive techniques. Convergence of estimated biomass to a desired neighborhood was proved based on the reduced model. The good performance of the control scheme was verified with full model simulations of the bioreactor simulations.

Index Terms:
Overflow metabolism, yeast, adaptive control, nonlinear control   

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