Modelización empírica simplificada de la actividad electrofisiológica en un haz de fibras mielínicas (A simplified empirical modeling of electrophysiological activity in a bundle of myelinated nerve fibers)

Alvaro Gabriel Pizá (, Fernando Daniel Farfán (, Ana Lía Albarracín (, Facundo Adrián Lucianna (, Jorge Humberto Soletta (, Carmelo José Felice (

1Universidad Nacional de Tucumán, Consejo Nacional de Investigaciones Científicas y Técnicas.

This paper appears in: Revista IEEE América Latina

Publication Date: July 2016
Volume: 14,   Issue: 7 
ISSN: 1548-0992

In vivo or in vitro electrophysiological characterization is a standard procedure to know specific aspects of the sensory and motor fibers conduction. In this work we propose a simplified empirical modeling that can predict the electrical activity evocated in a nerve by different experimental conditions. This approach includes physical and chemical concepts about the generation and propagation of myelin fiber action potentials, volume conduction and medium bioelectric properties; this was implemented by using simple qualitative parameters. The validation included the qualitative analysis of compound action potentials (CAPs) obtained from frog sciatic nerve in different experimental conditions and CAPs recordings obtained from infraorbital nerve in rats. The results reveal an adequate model fit to the CAPs waveform experimentally obtained. The intuitive parameters used in our approach facilitate the implementation and results interpretation, at the same time that provides versatility and robustness.

Index Terms:
Compound action potential, differential recording, electrophysiological characterization   

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